Journal: The British Journal of Radiology

Article Title: Functional MRI for quantitative treatment response prediction in locally advanced rectal cancer

doi: 10.1259/bjr.20151078

Figure Lengend Snippet: Diffusion-weighted imaging (DWI) MRI histogram analysis—apparent diffusion coefficient (ADC) colour-coded maps and histograms of a patient with good response following neoadjuvant chemoradiotherapy for rectal cancer. Example of ADC histogram analysis using Siemens OncoTreat (WIP), Erlangen, Germany. This patient had histological American Joint Committee on Cancer (7th edition) tumour regression grade 1 (moderate response, single cells or small groups of cancer cells). A voxel-by-voxel technique was used to assess changes in the entire region of interest. (a, c, e) Representative axial colour-coded ADC maps for MRI pre-chemoradiotherapy (CRT), Week 3 of CRT and post CRT, respectively. (b, d, f) Colour-coded histograms for every voxel within the segmented region of interest for DWI-MRI pre-CRT, Week 3 of CRT and post-CRT, respectively. Colour code: blue voxels, ADC values <1000 × 10−6; green voxels, ADC values 1000 − 1500 × 10−6; red voxels, ADC values >1500 × 10−6. The histograms demonstrate an increase in the absolute ADC values of voxels over the time points.

Article Snippet: Example of ADC histogram analysis using Siemens OncoTreat (WIP), Erlangen, Germany.

Techniques: Diffusion-based Assay, Imaging